01 — HARD TISSUE
Bone support
Grafts and bone-void fillers can maintain space, provide a scaffold, or fill a defect while bone forms and remodels.
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Clinical Education
Biomaterials that support the body’s. path to repair.
See how regenerative biomaterials are used in dental, orthopedic, and wound-care settings--from placement to healing.
The fundamentals
Two tissue systems.
One goal: regeneration.
Regenerative biomaterials are selected for the tissue being treated, the shape and location of the defect, and the clinical objective.
02 — SOFT TISSUE
Protection & reinforcement
Membranes, matrices, and collagen scaffolds can protect a site, guide healing, or reinforce repaired tissue.
Clinical applications
Where regenerative materials are used.
Select a clinical area to explore typical uses. The precise indication, handling method, and expected outcome depend on the specific product and patient.
01
Dental & maxillofacial
Hard tissue
Supporting bone regeneration
Bone grafting materials are placed into a prepared defect to provide space and a scaffold for new bone formation.
Typical clinical uses
- Preserving the jaw ridge after tooth extraction
- Augmenting an alveolar ridge before implant placement
- Filling periodontal, peri-implant, or cyst-removal defects
- Supporting maxillary sinus floor elevation procedures
Defect prepared
Graft placed
New bone remodels
Soft tissue
Protecting the healing site
Resorbable or non-resorbable barrier membranes separate faster-growing soft tissue from the bone-regeneration space. Other collagen materials may protect oral wounds.
Typical clinical uses
- Guided bone and guided tissue regeneration
- Extraction sockets and periodontal defects
- Implant dehiscence and fenestration defects
- Temporary protection of oral mucosal wounds
Membrane positioned
Site protected
Tissue heals
02
Orthopedic
Hard tissue
Filling bone voids and supporting fixation
Bone-void fillers occupy surgically created or traumatic defects that are not essential to the immediate stability of the bone. Product-specific formulations may have specialized uses.
Typical clinical uses
- Non-structural skeletal defects after trauma or surgery
- Selected joint-replacement fixation procedures
- Selected vertebroplasty or kyphoplasty procedures
- Product-specific infection-management or fixation applications
Void assessed
Material implanted
Bone heals or remodels
Soft tissue
Reinforcing repaired tissue
A biologic scaffold may be positioned over or around repaired tissue to add reinforcement while the patient’s tissue heals. It does not replace the primary repair.
Typical clinical uses
- Tendon repair with sutures or suture anchors
- Ligament repair where tissue weakness is present
- Reinforcement of selected partial meniscus defects
- Product-specific soft-tissue repair procedures
Tissue repaired
Scaffold secured
Repair remodels
03
Skin & wound care
Soft tissue
Creating a healing environment
Collagen-based powders, matrices, and tissue-derived coverings may help manage the wound environment and provide a scaffold for cell migration and new extracellular matrix deposition.
Typical clinical uses
- Acute and chronic wounds, when specified by the product
- Partial- and full-thickness wounds
- Surgical wounds and donor sites
- Pressure, venous, or diabetic ulcers when indicated
Wound prepared
Material applied
Healing monitored
Clinical literature
Explore the evidence behind clinical use.
Selected peer-reviewed resources provide a starting point for understanding the clinical evidence supporting regenerative biomaterials across dental, orthopedic, and wound-care settings.
Links open the PubMed record for each publication.Dental
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Bone graft and resorbable membrane for alveolar ridge preservation
Evaluates dimensional ridge preservation after extraction when graft materials are used with a resorbable membrane.
View on PubMed -
Effect of membrane exposure on guided bone regeneration
Examines how membrane exposure can affect bone-gain outcomes in peri-implant and edentulous-ridge procedures.
View on PubMed
Orthopedic
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Calcium phosphate bone cement in fracture treatment
Reviews clinical and radiographic outcomes of calcium-phosphate cement used in adult appendicular fractures.
View on PubMed -
Allograft versus demineralized bone matrix in lumbar fusion
Summarizes reported fusion outcomes for allograft and DBM in instrumented and noninstrumented lumbar procedures.
View on PubMed -
Resorbable collagen scaffolds for meniscus defects
Reviews clinical, imaging, arthroscopic, and histologic outcomes following collagen meniscus scaffold implantation.
View on PubMed
Wound care
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Clinical efficacy of collagen dressings on chronic wounds
Synthesizes randomized evidence comparing collagen dressings plus standard care with standard care alone.
View on PubMed -
MMP-inhibiting dressings for chronic wounds
Assesses randomized evidence for collagen and other MMP-modulating dressings across hard-to-heal wound types.
View on PubMed
For patients & partners
What to know before a biomaterial is used.
Does a regenerative biomaterial “grow” new tissue?
Most products provide a scaffold, barrier, filler, or reinforcement that supports the body’s healing process. The biological response varies by material, procedure, and patient.
Does the material remain in the body permanently?
Some materials resorb or remodel over time, while others are designed to remain. Your clinician should explain the specific product selected for your procedure.
Are all products used for the same indications?
No. Products that look similar can have different cleared or approved indications, contraindications, handling instructions, and clinical evidence.
What should patients ask their clinician?
Ask what material will be used, why it was selected, its source, whether it resorbs, important risks, alternatives, and what to expect during recovery.
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Advancing the standard of care to improve patient outcomes.
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